Pain at the base of the thumb
In De Quervain’s syndrome, the sheath of the APL and EPB tendons in the first dorsal extensor compartment of the wrist becomes thickened and constricted. This results in increased friction and mechanical irritation as the tendons move, producing pain over the radial styloid that is aggravated by thumb motion, gripping, pinching and ulnar deviation of the wrist. Patients often describe sharp or aching pain when lifting a baby, a pan or a shopping bag by its handle, as well as discomfort when wringing cloths, turning keys or performing repetitive smartphone or gaming actions.
Diagnosis is mainly clinical, based on focal tenderness over the first dorsal compartment and reproduction of pain with provocative tests such as the Finkelstein or Eichhoff manoeuvre. Ultrasound or MRI can be used when the presentation is atypical or symptoms do not follow the expected pattern, revealing tendon sheath thickening, fluid and synovial changes and helping to rule out differential diagnoses such as thumb CMC arthritis or intersection syndrome. Most cases follow a benign course, with many improving under appropriate education, activity modification and graded rehabilitation strategies.